Target Identification for a Promising Anti-Lupus Drug

Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis

Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kD...

TAFI: a promising drug target?

420 Thrombin-activatable fibrinolysis inhibitor (TAFI) is a 60kDa metallocarboxypeptidase produced by the liver and present in plasma. Independently discovered by several groups, the enzyme is also known as plasma procarboxypeptidase B, procarboxypeptidase R, or procarboxypeptidase U (1-5). TAFI as nomenclature was introduced by Bajar et al. (5). TAFI is expressed as a latent precursor requirin...

Centrosome – a promising anti-cancer target

The centrosome, an organelle discovered >100 years ago, is the main microtubule-organizing center in mammalian organisms. The centrosome is composed of a pair of centrioles surrounded by the pericentriolar material (PMC) and plays a major role in the regulation of cell cycle transitions (G1-S, G2-M, and metaphase-anaphase), ensuring the normality of cell division. Hundreds of proteins found in ...

Apelin: A promising therapeutic target? (Part 1)

Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...

Carbon Nanotubes: a Promising Approach for Drug Delivery